Get the Cubs vs. Padres prediction, odds, player props, and betting picks.
Two of the National League’s top bats collide Tuesday night as the Chicago Cubs (11–8) visit the San Diego Padres (14–3) at Petco Park. First pitch is set for 9:40 PM ET, and the Cubs enter as slight road favorites at -140.
Kyle Tucker leads Chicago with 5 home runs and 18 RBI, while Fernando Tatis Jr. continues to power the Padres with 6 home runs, a .361 average, and a team-high 12 RBI.
This one features a strong pitching matchup: Shota Imanaga (2–1, 2.70 ERA) takes the hill for the Cubs, while Randy Vasquez (1–1) makes his fourth start of the year for San Diego.
Find the best baseball betting strategy here.
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📊 Where To Watch Cubs vs. Padres? (April 15, 2025)
🏟 Venue: Petco Park, San Diego, CA
🗓 Date: Tuesday, April 15, 2025
🕘 Time: 9:40 PM ET
📺 TV: MARQ (Cubs), SDPA (Padres)
📡 Stream: MLB.tv, Fubo
💸 Cubs vs. Padres Odds
| Bet Type | Odds |
| Moneyline | Cubs -140 / Padres +118 |
| Run Line | Cubs -1.5 |
| Total Runs (O/U) | 7.5 |
📌 Score Prediction: Padres 4, Cubs 3
📈 Lean: Padres ML (+118) | Under 7.5
🧠 Betting Insights & Trends
Moneyline Movement
- Cubs are 6–2 as moneyline favorites
- Padres are 4–2 as underdogs, including 2–1 at +118 or longer
- Cubs have gone 3–2 when favored at -140 or shorter
Over/Under Trends
- Cubs games: 12–5–1 to the over
- Padres games: 7–9 to the over
- Total set at 7.5: Market favors strong pitching and late-inning leverage
🧢 Pitching Matchup
| Pitcher | Team | Record | ERA | IP | K/BB |
| Shota Imanaga | Cubs | 2–1 | 2.70 | 23.1 | 14/4 |
| Randy Vasquez | Padres | 1–1 | 3.60 | 15.0 | 12/5 |
Imanaga has been efficient and limiting hard contact, while Vasquez has been steady with strong ground-ball rates.
💥 Top Player Props to Watch
| Prop Type | Player | Pick | Why We Like It |
| Total Bases | Fernando Tatis Jr. | Over 1.5 TB | Batting .361, slugging .667 |
| Hits | Kyle Tucker | Over 1.5 Hits | Leads Cubs in AVG & HRs |
| RBIs | Seiya Suzuki | Over 0.5 RBIs | Great vs. righties, 19 hits |
| Strikeouts | Imanaga | Over 5.5 Ks | Faces low-K Padres team |
🩹 Injury Report
Cubs
- Vidal Brujan (Elbow) – 10-Day IL
- Tyson Miller (Hip), Justin Steele (Elbow), Javier Assad (Oblique), Ryan Brasier (Hip) – 15-Day IL
Padres
- Jake Cronenworth (Rib), Lockridge & Merrill (Hamstring) – 10-Day IL
- Yu Darvish (Elbow), Reynolds (Foot), Hoeing (Shoulder) – 15-Day IL
- Brito, Waldron, Musgrove – 60-Day IL
🔥 Same-Game Parlay (SGP) Pick
- ✅ Padres Moneyline (+118)
- ✅ Tatis Over 1.5 TB
- ✅ Under 7.5 Runs
🎯 Projected SGP Odds: +475
📱 Available at FanDuel, Caesars, DraftKings
✅ ClutchBuzz Final Cubs vs. Padres Prediction
- Top Bet: Padres +118 ML
- Lean: Under 7.5 Runs
- Best Prop: Tatis Over 1.5 Total Bases
- SGP Option: Padres ML + Tatis TB + Under 7.5 (+475)
- Score Prediction: Padres 4 – Cubs 3
