Check the Padres vs. Cubs prediction here. The Chicago Cubs (12-8) and San Diego Padres (14-4) meet in a rubber match this Wednesday, April 16 at 4:10 p.m. ET at PETCO Park. With the series tied 1-1, both clubs will send red-hot arms to the mound in what’s shaping up to be a tight pitching duel.
Nick Pivetta gets the ball for the Padres, who are currently -124 favorites, while the underdog Cubs (+105) counter with crafty left-hander Matthew Boyd. The total is set at 7.5 runs, indicating oddsmakers expect a low-scoring battle between two efficient rotations.
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📊 Where To Watch Padres vs. Cubs? (April 16, 2025)
- Date: Wednesday, April 16, 2025
- Time: 4:10 p.m. ET
- Location: PETCO Park — San Diego, California
- TV Channels:
- San Diego: SDPA (San Diego Padres Broadcast)
- Chicago: MARQ (Marquee Sports Network)
- Live Stream:
- FuboTV (with regional access)
- MLB.TV (out-of-market only)
⚾ Cubs vs. Padres Key Matchup: Boyd vs. Pivetta
| Pitcher | Team | Record | ERA | IP | K | BB | BAA |
| Matthew Boyd | Cubs | 1-1 | 1.59 | 17 | 17 | 7 | .213 |
| Nick Pivetta | Padres | 2-1 | 1.59 | 17 | 18 | 4 | — |
- Boyd has logged back-to-back quality starts and boasts a strong 9.0 K/9 rate.
- Pivetta is coming off 7 scoreless innings vs. the Rockies and has held opponents to just 3 earned runs total across his first three starts.
Both pitchers average 5.7 innings per outing — keeping bullpens active and late-inning matchups critical.
📊 Betting Odds: Padres vs. Cubs
| Outcome | Odds |
| Padres ML | -124 |
| Cubs ML | +105 |
| Spread | Padres -1.5 |
| Total (O/U) | 7.5 runs |
🧢 Padres Team Stats & Trends
- Run Production: 4.7 runs/game (9th MLB)
- Batting Avg: .277 (2nd MLB)
- Strikeouts: 6.7 per game (3rd fewest)
- Team ERA: 2.59 (2nd MLB)
🔑 Padres Players to Watch
- Fernando Tatis Jr. – .354 AVG, 6 HR, 12 RBI
- Manny Machado – .387 OBP, .507 SLG
- Nick Pivetta – 2.1 BB/9, 9.5 K/9, 2 quality starts
🐻 Cubs Team Stats & Trends
- Run Production: MLB-best 122 runs
- Home Runs: 26 (4th in MLB)
- Batting Avg: .257 (6th MLB)
- Team ERA: 4.12 (17th MLB)
🔑 Cubs Players to Watch
- Kyle Tucker – 5 HR, 18 RBI
- Carson Kelly – .417 AVG, 4 HR
- Nico Hoerner – .328 AVG
- Matthew Boyd – 3 starts, 1.59 ERA, 17 Ks in 17 IP
🏥 Injury Report
🔹 Padres
- Joe Musgrove (Elbow) – 60-Day IL
- Yu Darvish (Elbow) – 15-Day IL
- Jackson Merrill (Hamstring) – 10-Day IL
🔹 Cubs
- Justin Steele (Elbow) – 15-Day IL
- Ryan Brasier (Hip) – 15-Day IL
- Javier Assad (Oblique) – 15-Day IL
🧠 ClutchBuzz Padres vs. Cubs Prediction & Best Bet
San Diego holds the edge in starting pitching and plate discipline. Both starters have been stingy, but with PETCO Park’s pitcher-friendly tendencies and the strength of these lineups, we like the under here.
🏆 Score Prediction: Padres 4, Cubs 3
💰 Best Bet: Under 7.5 Total Runs
