Red Sox vs. White Sox Prediction, Odds, Pitching Matchup & Picks (April 18, 2025)

Check the latest Red Sox vs. White Sox prediction for today. The Boston Red Sox (10-10) return home to Fenway Park to kick off a four-game set against the struggling Chicago White Sox (4-14) on Friday night. First pitch is scheduled for 7:10 p.m. ET, as Boston looks to capitalize on a team riding a four-game losing streak.

Hunter Dobbins will take the mound for the Red Sox, making just his second start of the season, while the White Sox counter with veteran lefty Martín Pérez, who has quietly been one of the league’s most effective starters early this year.

Let’s break down the betting lines, player props, key injuries, and our final score prediction for this AL matchup.

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📺 Where To Watch Red Sox vs. White Sox? (April 18, 2025)

💰 Red Sox vs. White Sox Odds

Odds are subject to change. Check on FanDuel, Caesars and bet365 for latest updates.

📈 Betting Trends

• Red Sox are 7-6 as moneyline favorites this season and 1-1 when favored by -205 or shorter.
• White Sox have lost all four games this year when listed as +170 or greater underdogs.
• Total has gone OVER in 7 of Boston’s 20 games and in 7 of Chicago’s 18.

🧠 Red Sox vs. White Sox Prediction

Boston enters this game with a pitching advantage on paper, despite Dobbins’ inexperience. Martín Pérez has been sharp to open 2025, but he’ll need run support — something the White Sox have sorely lacked.

The Red Sox are averaging 4.3 runs per game and hitting .247 as a team, while the White Sox are dead last in MLB in batting average (.196) and rank 29th in total runs. Despite a stellar 1.59 ERA for Pérez, Chicago’s offense is simply too cold to back here.

🔮 Final Score Prediction: Red Sox 6, White Sox 5

💣 Total Prediction: Over 9 Runs

🥊 Starting Pitching Matchup

Hunter Dobbins (BOS)

• 1-0, 3.60 ERA, 5.0 IP
• 9.0 K/9, .381 BAA
• Making his second MLB start after a solid debut

Martín Pérez (CHW)

• 1-0, 1.59 ERA, 17.2 IP
• 18 K, .158 BAA
• Allowed 2 ER in 4.2 IP in his last start vs Boston

📊 Player Props to Watch

Top Player Prop Bet:

• Wilyer Abreu 2+ Total Bases (+125)
  Abreu leads the Sox in average and RBI. Expect him to stay hot against a lefty-heavy bullpen.

🧾 Same-Game Parlay (SGP)

🔥 +390 Odds

• Red Sox Moneyline ✅
• Total Over 9 ✅
• Pérez Under 6.5 Strikeouts ✅

Boston has struck out more than any team this season, but with Pérez likely on a short leash, the UNDER in K’s provides strong value.

🤕 Injury Report

🔴 Red Sox

• Connor Wong (Hand) – 10-Day IL
• Masataka Yoshida (Shoulder) – 10-Day IL
• Brayan Bello (Shoulder) – 15-Day IL
• Kutter Crawford (Knee) – 15-Day IL
• Liam Hendriks, Lucas Giolito, Richard Fitts – All out

⚫ White Sox

• Austin Slater, Mike Tauchman, Korey Lee – 10-Day IL
• Josh Rojas (Toe) – 10-Day IL
• Berroa, Bush, Thorpe, Scholtens – All on 60-Day IL

📌 ClutchBuzz Red Sox vs. White Sox Prediction

Boston has a clear offensive edge and the bullpen to support their rookie starter. Martín Pérez may limit damage early, but it’s tough to trust a White Sox team that’s slashing just .179 over its last 10.

🔒 Best Bets

• Red Sox ML (-205)
• Total Over 9 (-110)
• Wilyer Abreu 2+ Total Bases (+125)

Stay locked in with ClutchBuzz for more MLB betting previews and sharp picks all season long.