We’ve made it to the final stop on the road to the 2025 NCAA Tournament championship, and the buzz surrounding this year’s Final Four odds is absolutely electric. For just the second time since 1985, all four No. 1 seeds have reached the Final Four: Duke, Florida, Houston, and Auburn. There are no Cinderellas this year—just college basketball royalty ready to battle it out in San Antonio.
And leading the pack? The Duke Blue Devils, who open as favorites in the latest odds to win the national title. But the field is tight. Let’s break down the March Madness odds, betting lines, and key matchups heading into this historic weekend.
2025 Final Four Odds: Who’s the Favorite to Win It All?
Let’s get right into the national championship odds entering Saturday’s national semifinals:
| Team | Odds to Win |
| Duke Blue Devils | +105 |
| Florida Gators | +260 |
| Houston Cougars | +400 |
| Auburn Tigers | +500 |
The Blue Devils may be the chalk pick, but betting value exists deeper in the field—especially with Florida and Houston, who have looked like complete teams throughout the NCAA Tournament.
Surprisingly, the Auburn Tigers, who entered March as the No. 1 overall seed, now hold the longest odds after star big man Johni Broome was injured in their Elite Eight win. That scare caused sportsbooks to adjust their lines, dropping Auburn’s odds from +410 to +500.
Confused on how to bet on March Madness? Check our guide here.
Game Lines: Final Four 2025 Schedule and Spreads
🏀 (1) Florida Gators vs. (1) Auburn Tigers
Tip-Off: Saturday, April 5 — 6:09 p.m. ET
Location: San Antonio, Texas
| Bet Type | Florida Gators | Auburn Tigers |
| Spread | -2.5 (-110) | +2.5 (-110) |
| Moneyline | -145 to -152 | +122 to +126 |
| Total Points | Over/Under 161.5 |
This spread might surprise some. The Tigers were once favored to reach the final game, but the Gators already beat them in the regular season, winning by nine points on the road—and without star guard Alijah Martin. With Martin back and healthy, Florida is trending in the right direction at just the right time.
Check out complete detailed preview for Florida vs Auburn here.
🏀 (1) Duke Blue Devils vs. (1) Houston Cougars
Tip-Off: Saturday, April 5 — 8:49 p.m. ET
| Bet Type | Duke Blue Devils | Houston Cougars |
| Spread | -4.5 | +4.5 |
| Moneyline | -210 | +175 |
| Total Points | Over/Under 137 |
This game is a rematch of last year’s Sweet 16, where Duke knocked out Houston in a tight contest. That loss came without Jamal Shead for most of the game, but the Cougars are at full strength now and boast arguably the best defense in the college basketball world.
Still, Duke’s offense has been red-hot in this year’s NCAA Tournament, shooting 47.3% from three-point range. Guard Tyrese Proctor has emerged as a true March Madness star, hitting over 64% of his three-point shots. If Duke continues this efficiency, it’s hard to see anyone stopping them.
Check out complete detailed preview for Duke vs Houston here.
March Madness Odds Movement: How the Lines Have Shifted
The March Madness odds have been fascinating to watch as the tournament has progressed. Heading into the Sweet 16, all four of these teams were among the betting favorites. Since then, the favorites have gone a perfect 12-0, setting the stage for this elite Final Four.
The latest odds moved significantly following Auburn’s injury scare, while Florida’s odds to win surged based on their previous head-to-head success and clean bill of health.
North Carolina State’s DJ Burns Jr. (30) shoots against Duke’s Sean Stewart (13) during the second half of an Elite Eight college basketball game in the NCAA Tournament in Dallas, Sunday, March 31, 2024. North Carolina State won 76-64. (AP Photo/Julio Cortez)
Betting Analysis: Who Offers the Best Value?
Let’s evaluate the remaining four teams based on both talent and Final Four odds.
Duke Blue Devils (+105)
- Strengths: Perimeter shooting, depth, veteran leadership
- Weaknesses: Can go cold from deep if pressured
- Outlook: They’re peaking at the perfect time. If they beat Houston, they’ll be favored in the final.
Florida Gators (+260)
- Strengths: SEC-tested, battle-ready, strong guard play
- Weaknesses: Inconsistent scoring in close games
- Outlook: Already beat Auburn. If they do it again, they may ride the momentum to a national championship.
Houston Cougars (+400)
- Strengths: Lockdown defense, elite rebounding, experience
- Weaknesses: Slower tempo could hurt if they fall behind
- Outlook: They’ve made a living shutting down top offenses, but Duke will be their biggest challenge yet.
Auburn Tigers (+500)
- Strengths: Length, speed, transition game
- Weaknesses: Injuries, especially to Broome
- Outlook: They’ll need Broome close to 100% to get past Florida and keep their title hopes alive.
Historical Note: Four No. 1 Seeds Again in San Antonio
The last—and only—time all four No. 1 seeds reached the Final Four was in 2008, also in San Antonio. That tournament featured Kansas, Memphis, UCLA, and UNC. This year feels just as stacked, and there’s no denying that the best of the best are left standing.
Three games remaining, and the national title is up for grabs.
Best Bets: Final Four Odds Picks and Predictions
If you’re placing your March Madness bets, here are our top recommendations:
- Best Value: Houston (+400) – If you believe defense wins championships, this is your pick.
- Best Hedge: If you already have Auburn futures like I do, consider backing Florida to hedge.
- Best Over/Under Play: Florida vs. Auburn Over 161.5 – Both teams love to push the pace and shoot the three.
- Best Straight Bet: Duke -4.5 – Too much firepower and too much momentum.
Final Four Parlay Picks: Best Bets to Maximize Your March Madness Winnings
If you’re looking to go beyond straight bets, this is the perfect weekend to get creative with your Final Four wagers. Here are a few parlay ideas to consider, whether you like playing it safe or swinging for a high-payout longshot.
🔥 Safe Play Parlay (Low Risk, Steady Return)
- Duke ML (-210)
- Florida +2.5 (-110)
Payout: ~$160 on a $100 bet
Why it works: Duke has been dominant and matches up well against Houston, while Florida already beat Auburn once and is the healthier team entering Saturday.
🎯 Spread Confidence Parlay
- Duke -4.5
- Florida -2.5
Payout: ~$265 on a $100 bet
Why it works: If you believe both favorites are going to win and cover, this gives you much better value than taking two moneylines.
💰 Final & Futures Combo Parlay
- Duke ML (-210)
- Florida ML (-145)
- Duke to Win the National Championship (+105)
Payout: ~$450 on a $100 bet
Why it works: This assumes Duke beats Houston, Florida takes care of Auburn, and Duke finishes the job Monday night. A three-leg combo with a realistic path.
🚀 High-Risk, High-Reward Parlay
- Auburn ML (+126)
- Houston ML (+175)
- Houston to Win the National Championship (+400)
Payout: ~$1,050+ on a $100 bet
Why it works: Bet on the chaos. Auburn and Houston are both underdogs with strong rosters and legit paths to the title. If both pull upsets Saturday, you’re set up for a massive hit.
🧠 Totals Parlay
- Florida vs. Auburn Over 161.5
- Duke vs. Houston Under 137
Payout: ~$260 on a $100 bet
Why it works: The first semifinal is expected to be a track meet, while the second could slow down due to Houston’s elite defense. Bet on pace differences to hit both totals.
🏆 All-In National Champion Parlay
- Duke -4.5
- Duke to Win the National Championship (+105)
Payout: ~$290 on a $100 bet
Why it works: If you’re all-in on Duke, this gives you exposure to both their semifinal and final with a strong combined value.
Where to Bet the Final Four Odds
Looking to lock in your bets? Check out bet365, DraftKings, and Caesars for the most competitive lines and Final Four promos. If you’re in Colorado, don’t miss the Fanatics Colorado bonus code for an exclusive first bet offer.
Final Thoughts: Countdown to the National Championship
The Final Four odds suggest a tight, hard-fought finish to one of the best tournaments in recent memory. With Duke, Florida, Houston, and Auburn all looking the part, it’s anyone’s title to win.
One thing’s for sure: fans are in for a wild ride in San Antonio. Whether you’re backing the Blue Devils or chasing a longshot with the Auburn Tigers, get ready for a final weekend of college hoops that could go down in history.
